CircRNA hsa_circ_0030018 regulates the development of glioma via regulating the miR-1297/RAB21 axis

Circular RNAs (circRNAs) play a crucial role in tumor occurrence and progression. And the dysregulated circRNAs are reported to be relevant glioma development. Nevertheless, function regulatory mechanism of hsa_circ_0030018 progression largely indistinct. The abundances hsa_circ_0030018, miR-1297, RAB21 were detected using quantitative real-time polymerase chain reaction or western blot. Cell proliferation was assessed via colony formation assay 3-(4,5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay. apoptosis cell cycle evaluated by flow cytometry. migration invasion examined transwell wound healing protein levels measured interaction between miR-1297 validated dual-luciferase reporter analysis, RNA immunoprecipitation (RIP), pull-down assays. A xenograft model experiment performed analyze on growth vivo. enhanced, level reduced tissues cells. silence overexpression impeded proliferation, metastasis, expedited arrest Furthermore, modulated malignant behaviors sponging suppressed development targeting RAB21. Moreover, knockdown inhibited repressed mediating miR-1297/RAB21 pathway, providing potential therapeutic targets for treatment.